Drug interactions
Chlorpheniramine + Loxapine
Severity: Moderate
Chlorpheniramine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a first-generation antihistamine that causes drowsiness and has anticholinergic effects. With loxapine it may produce excessive sedation, slowed reaction time and additive anticholinergic symptoms, particularly in elderly patients.
What this interaction means in plain words
Chlorpheniramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1 antagonism and antipsychotic receptor blockade, with additive antimuscarinic activity.
What to do
Counsel the patient on drowsiness and avoidance of driving or hazardous tasks. Prefer a non-sedating antihistamine when an antihistamine is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Loxapine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a first-generation antihistamine that causes drowsiness and has anticholinergic effects. With loxapine it may produce excessive sedation, slowed reaction time and additive anticholinergic symptoms, particularly in elderly patients.
How serious is the interaction between Chlorpheniramine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on drowsiness and avoidance of driving or hazardous tasks. Prefer a non-sedating antihistamine when an antihistamine is required.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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