Drug interactions
Chlorpheniramine + Metaxalone
Severity: Moderate
Chlorpheniramine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine, and with metaxalone the sedative effects may add together. This can impair alertness and coordination.
What this interaction means in plain words
Chlorpheniramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and metaxalone sedation.
What to do
Monitor for drowsiness and consider a non-sedating antihistamine. Advise patients to avoid driving if they feel sedated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Metaxalone?
MediHelp rates the interaction as moderate. Chlorpheniramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine, and with metaxalone the sedative effects may add together. This can impair alertness and coordination.
How serious is the interaction between Chlorpheniramine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and consider a non-sedating antihistamine. Advise patients to avoid driving if they feel sedated.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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