Drug interactions
Chlorpheniramine + Methohexital
Severity: Moderate
Chlorpheniramine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, so combining them increases sedation and may deepen anesthesia or prolong recovery. Respiratory depression and psychomotor impairment are more likely.
What this interaction means in plain words
Chlorpheniramine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression from sedating H1-antihistamine activity plus barbiturate GABA-A potentiation.
What to do
Monitor sedation level and respiratory function closely, and titrate methohexital to effect with a lower dose if the patient recently took chlorpheniramine. Ensure airway equipment and monitoring are available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Methohexital
Frequently asked questions
Can I take Chlorpheniramine with Methohexital?
MediHelp rates the interaction as moderate. Chlorpheniramine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, so combining them increases sedation and may deepen anesthesia or prolong recovery. Respiratory depression and psychomotor impairment are more likely.
How serious is the interaction between Chlorpheniramine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory function closely, and titrate methohexital to effect with a lower dose if the patient recently took chlorpheniramine. Ensure airway equipment and monitoring are available.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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