Drug interactions
Chlorpheniramine + Mitotane
Severity: Minor
Chlorpheniramine and Mitotane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong inducer of CYP3A4 and may lower exposure to drugs cleared by this pathway. Chlorpheniramine concentrations may fall, potentially reducing its antihistaminic effect.
What this interaction means in plain words
Chlorpheniramine and Mitotane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Mitotane belongs to Oncology.
Why it happens
Mitotane-mediated induction of hepatic and intestinal CYP3A4 increases chlorpheniramine metabolism.
What to do
Monitor for reduced antihistamine efficacy and increase the dose or switch agents if symptom control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Chlorpheniramine with Mitotane?
MediHelp rates the interaction as minor. Chlorpheniramine and Mitotane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mitotane is a strong inducer of CYP3A4 and may lower exposure to drugs cleared by this pathway. Chlorpheniramine concentrations may fall, potentially reducing its antihistaminic effect.
How serious is the interaction between Chlorpheniramine and Mitotane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antihistamine efficacy and increase the dose or switch agents if symptom control is inadequate.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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