Drug interactions
Chlorpheniramine + Quetiapine
Severity: Moderate
Chlorpheniramine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so combined use can increase drowsiness, impair alertness and add to anticholinergic effects.
What this interaction means in plain words
Chlorpheniramine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Quetiapine belongs to Central Nervous System.
Why it happens
Additive H1 antihistaminic CNS depression and antimuscarinic activity.
What to do
Warn about sedation and avoid driving until response is known; consider a non-sedating antihistamine, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Quetiapine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so combined use can increase drowsiness, impair alertness and add to anticholinergic effects.
How serious is the interaction between Chlorpheniramine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about sedation and avoid driving until response is known; consider a non-sedating antihistamine, especially in older adults.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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