Drug interactions
Chlorpheniramine + Voxelotor
Severity: Minor
Chlorpheniramine and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and may modestly raise chlorpheniramine levels. Chlorpheniramine has a wide therapeutic margin, so clinical effects are likely limited to more sedation or anticholinergic effects.
What this interaction means in plain words
Chlorpheniramine and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpheniramine belongs to Respiratory; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibition of CYP3A4 reduces metabolic clearance of chlorpheniramine.
What to do
No routine adjustment is required. Counsel about increased drowsiness and consider lowering the chlorpheniramine dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpheniramine
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Chlorpheniramine with Voxelotor?
MediHelp rates the interaction as minor. Chlorpheniramine and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor can inhibit CYP3A4 and may modestly raise chlorpheniramine levels. Chlorpheniramine has a wide therapeutic margin, so clinical effects are likely limited to more sedation or anticholinergic effects.
How serious is the interaction between Chlorpheniramine and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Counsel about increased drowsiness and consider lowering the chlorpheniramine dose if symptoms occur.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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