Drug interactions
Chlorpromazine + Droperidol
Severity: Contraindicated
Chlorpromazine and Droperidol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dopamine antagonists that prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use markedly increases arrhythmia risk and additive sedation.
What this interaction means in plain words
Chlorpromazine and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive blockade of cardiac potassium channels with QT prolongation, plus additive CNS depression.
What to do
Avoid using together; select an antiemetic or sedative without QT effects. If unavoidable, use continuous ECG monitoring and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Chlorpromazine + Pimozide Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Droperidol?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are dopamine antagonists that prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use markedly increases arrhythmia risk and additive sedation.
How serious is the interaction between Chlorpromazine and Droperidol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using together; select an antiemetic or sedative without QT effects. If unavoidable, use continuous ECG monitoring and correct electrolytes.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Chlorpromazine page.
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