Drug interactions
Chlorpromazine + Dofetilide
Severity: Contraindicated
Chlorpromazine and Dofetilide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide has a narrow therapeutic window and causes dose-related QT prolongation and torsades de pointes. Chlorpromazine adds further QT prolongation and raises arrhythmia risk.
What this interaction means in plain words
Chlorpromazine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chlorpromazine belongs to Central Nervous System; Dofetilide belongs to Cardiovascular.
Why it happens
Additive delayed ventricular repolarization through potassium channel blockade.
What to do
Do not co-administer; choose a non-QT-prolonging alternative for either drug. If an antipsychotic is essential, consult cardiology.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Chlorpromazine + Pimozide Contraindicated
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Dofetilide?
MediHelp rates the interaction as contraindicated. Chlorpromazine and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dofetilide has a narrow therapeutic window and causes dose-related QT prolongation and torsades de pointes. Chlorpromazine adds further QT prolongation and raises arrhythmia risk.
How serious is the interaction between Chlorpromazine and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose a non-QT-prolonging alternative for either drug. If an antipsychotic is essential, consult cardiology.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dronedarone, Droperidol, Ibutilide. The full list is on the Chlorpromazine page.
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