Drug interactions
Chlorpropamide + Clomipramine
Severity: Minor
Chlorpropamide and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter glucose control, and hypoglycemia has been reported with them in patients taking antidiabetic drugs. The effect is variable and usually modest, but glucose control may shift when clomipramine is started or stopped.
What this interaction means in plain words
Chlorpropamide and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Clomipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic effects on glucose homeostasis; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping clomipramine in a patient on chlorpropamide. Adjust the antidiabetic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Clomipramine?
MediHelp rates the interaction as minor. Chlorpropamide and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can alter glucose control, and hypoglycemia has been reported with them in patients taking antidiabetic drugs. The effect is variable and usually modest, but glucose control may shift when clomipramine is started or stopped.
How serious is the interaction between Chlorpropamide and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping clomipramine in a patient on chlorpropamide. Adjust the antidiabetic dose if needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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