Drug interactions
Chlorpropamide + Dronabinol
Severity: Moderate
Chlorpropamide and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol oral solution contains a high ethanol content, and chlorpropamide can cause a disulfiram-like reaction with alcohol. Flushing, nausea and palpitations could result, whereas the capsule formulation carries no such ethanol load.
What this interaction means in plain words
Chlorpropamide and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Dronabinol belongs to Central Nervous System.
Why it happens
Chlorpropamide inhibition of aldehyde dehydrogenase causes disulfiram-like reaction with ethanol in the dronabinol solution
What to do
Avoid the alcohol-containing oral solution in patients taking chlorpropamide; use capsules or an alternative sulfonylurea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Chlorpropamide with Dronabinol?
MediHelp rates the interaction as moderate. Chlorpropamide and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronabinol oral solution contains a high ethanol content, and chlorpropamide can cause a disulfiram-like reaction with alcohol. Flushing, nausea and palpitations could result, whereas the capsule formulation carries no such ethanol load.
How serious is the interaction between Chlorpropamide and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the alcohol-containing oral solution in patients taking chlorpropamide; use capsules or an alternative sulfonylurea.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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