Drug interactions
Chlorpropamide + Hydrochlorothiazide-lisinopril
Severity: Moderate
Chlorpropamide and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and so reduce the effect of chlorpropamide, and they may compete with it for renal secretion. Chlorpropamide has a long half-life, and thiazide-induced hyponatremia may add to its risk of SIADH-like effects.
What this interaction means in plain words
Chlorpropamide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Thiazide-induced impairment of glucose tolerance opposes sulfonylurea action, with possible competition for renal tubular secretion and additive hyponatremia.
What to do
Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen as needed; consider a safer sulfonylurea alternative in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Chlorpropamide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can raise blood glucose and so reduce the effect of chlorpropamide, and they may compete with it for renal secretion. Chlorpropamide has a long half-life, and thiazide-induced hyponatremia may add to its risk of SIADH-like effects.
How serious is the interaction between Chlorpropamide and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen as needed; consider a safer sulfonylurea alternative in older patients.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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