Drug interactions
Chlorpropamide + Iloperidone
Severity: Moderate
Chlorpropamide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone can cause hyperglycemia and metabolic changes that oppose the effect of antidiabetic drugs. Glycemic control in a patient on chlorpropamide may deteriorate.
What this interaction means in plain words
Chlorpropamide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-induced insulin resistance and impaired glucose regulation oppose the sulfonylurea effect.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and increase or adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Chlorpropamide with Iloperidone?
MediHelp rates the interaction as moderate. Chlorpropamide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone can cause hyperglycemia and metabolic changes that oppose the effect of antidiabetic drugs. Glycemic control in a patient on chlorpropamide may deteriorate.
How serious is the interaction between Chlorpropamide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and increase or adjust antidiabetic therapy as needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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