Drug interactions
Chlorpropamide + Insulin glargine
Severity: Moderate
Chlorpropamide and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide with insulin glargine produces additive glucose lowering with risk of severe and prolonged hypoglycemia, as chlorpropamide has a long half-life and renal clearance.
What this interaction means in plain words
Chlorpropamide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive effect of exogenous insulin and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor glucose closely, particularly in older or renally impaired patients, and reduce the insulin or chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Insulin glargine?
MediHelp rates the interaction as moderate. Chlorpropamide and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpropamide with insulin glargine produces additive glucose lowering with risk of severe and prolonged hypoglycemia, as chlorpropamide has a long half-life and renal clearance.
How serious is the interaction between Chlorpropamide and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely, particularly in older or renally impaired patients, and reduce the insulin or chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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