Drug interactions
Chlorpropamide + Itraconazole
Severity: Minor
Chlorpropamide and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide is largely excreted unchanged and has limited CYP involvement, so a clinically meaningful effect of itraconazole is not well established. Azoles can however alter sulfonylurea effect, so glucose changes are possible.
What this interaction means in plain words
Chlorpropamide and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
No well-established mechanism; any effect would be through altered hepatic metabolism of the sulfonylurea.
What to do
Monitor blood glucose when starting or stopping itraconazole and adjust the chlorpropamide dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Itraconazole?
MediHelp rates the interaction as minor. Chlorpropamide and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpropamide is largely excreted unchanged and has limited CYP involvement, so a clinically meaningful effect of itraconazole is not well established. Azoles can however alter sulfonylurea effect, so glucose changes are possible.
How serious is the interaction between Chlorpropamide and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping itraconazole and adjust the chlorpropamide dose if control changes.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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