Drug interactions
Chlorpropamide + Liraglutide
Severity: Moderate
Chlorpropamide and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide enhances glucose-dependent insulin secretion, and chlorpropamide stimulates insulin release independently of glucose. Together they raise the likelihood of hypoglycemia, which can be prolonged with chlorpropamide because of its long half-life.
What this interaction means in plain words
Chlorpropamide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects from combined insulin secretion stimulation.
What to do
Consider reducing the chlorpropamide dose when starting liraglutide and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Liraglutide
Frequently asked questions
Can I take Chlorpropamide with Liraglutide?
MediHelp rates the interaction as moderate. Chlorpropamide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide enhances glucose-dependent insulin secretion, and chlorpropamide stimulates insulin release independently of glucose. Together they raise the likelihood of hypoglycemia, which can be prolonged with chlorpropamide because of its long half-life.
How serious is the interaction between Chlorpropamide and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when starting liraglutide and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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