Drug interactions
Chlorpropamide + Lornoxicam
Severity: Moderate
Chlorpropamide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam may potentiate the glucose-lowering effect of sulfonylureas, leading to hypoglycemia. Lornoxicam may also impair renal function, which can prolong exposure to chlorpropamide, a renally eliminated drug.
What this interaction means in plain words
Chlorpropamide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced renal clearance; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping lornoxicam and reduce the sulfonylurea dose if hypoglycemia occurs. Check renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Lornoxicam
Frequently asked questions
Can I take Chlorpropamide with Lornoxicam?
MediHelp rates the interaction as moderate. Chlorpropamide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam may potentiate the glucose-lowering effect of sulfonylureas, leading to hypoglycemia. Lornoxicam may also impair renal function, which can prolong exposure to chlorpropamide, a renally eliminated drug.
How serious is the interaction between Chlorpropamide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lornoxicam and reduce the sulfonylurea dose if hypoglycemia occurs. Check renal function in at-risk patients.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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