Drug interactions
Chlorpropamide + Lurasidone
Severity: Moderate
Chlorpropamide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and worsen glycemic control. Lurasidone has a relatively low metabolic risk, but it may still reduce the effectiveness of chlorpropamide in diabetic patients.
What this interaction means in plain words
Chlorpropamide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related impairment of glucose regulation opposes the sulfonylurea's glucose-lowering effect.
What to do
Monitor blood glucose and HbA1c after starting or changing lurasidone. Adjust the antidiabetic regimen as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Lurasidone?
MediHelp rates the interaction as moderate. Chlorpropamide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics can cause hyperglycemia and worsen glycemic control. Lurasidone has a relatively low metabolic risk, but it may still reduce the effectiveness of chlorpropamide in diabetic patients.
How serious is the interaction between Chlorpropamide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing lurasidone. Adjust the antidiabetic regimen as required.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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