Drug interactions
Chlorpropamide + Moxifloxacin
Severity: Moderate
Chlorpropamide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin can cause hypoglycemia or hyperglycemia, and sulfonylureas such as chlorpropamide increase vulnerability to low glucose. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
What this interaction means in plain words
Chlorpropamide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones promote insulin release through beta-cell potassium channel effects, additive to sulfonylurea action.
What to do
Monitor blood glucose closely during moxifloxacin therapy and warn the patient about hypoglycemia. Lower the sulfonylurea dose if needed or choose another antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Moxifloxacin?
MediHelp rates the interaction as moderate. Chlorpropamide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin can cause hypoglycemia or hyperglycemia, and sulfonylureas such as chlorpropamide increase vulnerability to low glucose. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
How serious is the interaction between Chlorpropamide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during moxifloxacin therapy and warn the patient about hypoglycemia. Lower the sulfonylurea dose if needed or choose another antibiotic.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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