Drug interactions
Chlorpropamide + Nabumetone
Severity: Moderate
Chlorpropamide and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, leading to hypoglycemia in some patients. Nabumetone has a weaker documented effect than some other NSAIDs, but the risk is greater with chlorpropamide because of its long half-life.
What this interaction means in plain words
Chlorpropamide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Nabumetone belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced renal clearance of the sulfonylurea; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping the NSAID and educate the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Nabumetone?
MediHelp rates the interaction as moderate. Chlorpropamide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, leading to hypoglycemia in some patients. Nabumetone has a weaker documented effect than some other NSAIDs, but the risk is greater with chlorpropamide because of its long half-life.
How serious is the interaction between Chlorpropamide and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and educate the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if glucose falls.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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