Drug interactions
Chlorpropamide + Piroxicam
Severity: Moderate
Chlorpropamide and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, which has a long half-life. Hypoglycemia is possible, especially in older patients or those with renal impairment.
What this interaction means in plain words
Chlorpropamide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and altered renal handling; the mechanism is not firmly established.
What to do
Check blood glucose when piroxicam is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Piroxicam?
MediHelp rates the interaction as moderate. Chlorpropamide and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may modestly enhance the glucose-lowering effect of sulfonylureas such as chlorpropamide, which has a long half-life. Hypoglycemia is possible, especially in older patients or those with renal impairment.
How serious is the interaction between Chlorpropamide and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose when piroxicam is started or stopped and counsel the patient on hypoglycemia symptoms. Reduce the sulfonylurea dose if needed.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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