Drug interactions
Chlorthalidone + Corticotropin
Severity: Moderate
Chlorthalidone and Corticotropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates adrenal steroid release with mineralocorticoid effects, and together with chlorthalidone this can increase potassium loss and cause hypokalemia. Fluid retention may also oppose the diuretic effect.
What this interaction means in plain words
Chlorthalidone and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Corticotropin belongs to Endocrine.
Why it happens
Additive potassium wasting from thiazide-type diuresis and corticotropin-induced corticosteroid and mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium during combined use. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorthalidone and Corticotropin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorthalidone
Other interactions of Corticotropin
Frequently asked questions
Can I take Chlorthalidone with Corticotropin?
MediHelp rates the interaction as moderate. Chlorthalidone and Corticotropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates adrenal steroid release with mineralocorticoid effects, and together with chlorthalidone this can increase potassium loss and cause hypokalemia. Fluid retention may also oppose the diuretic effect.
How serious is the interaction between Chlorthalidone and Corticotropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium during combined use. Replace potassium as needed.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
