Drug interactions
Chlorthalidone + Ethacrynic acid
Severity: Moderate
Chlorthalidone and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a thiazide-like diuretic with a loop diuretic produces sequential nephron blockade and a strong diuretic response. This can cause marked loss of potassium, magnesium and sodium, plus volume depletion, hypotension and renal impairment. Ethacrynic acid also carries a risk of ototoxicity that may be worsened by electrolyte disturbance and dehydration.
What this interaction means in plain words
Chlorthalidone and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive diuresis and electrolyte loss from blocking sodium reabsorption at the distal tubule and the loop of Henle.
What to do
Monitor potassium, magnesium, sodium, creatinine and volume status closely, particularly after starting or changing doses. Supplement electrolytes or reduce diuretic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Chlorthalidone with Ethacrynic acid?
MediHelp rates the interaction as moderate. Chlorthalidone and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a thiazide-like diuretic with a loop diuretic produces sequential nephron blockade and a strong diuretic response. This can cause marked loss of potassium, magnesium and sodium, plus volume depletion, hypotension and renal impairment. Ethacrynic acid also carries a risk of ototoxicity that may be worsened by electrolyte disturbance and dehydration.
How serious is the interaction between Chlorthalidone and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium, sodium, creatinine and volume status closely, particularly after starting or changing doses. Supplement electrolytes or reduce diuretic doses as needed.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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