Drug interactions
Chlorthalidone + Gentamicin
Severity: Moderate
Chlorthalidone and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone causes potassium and magnesium loss, and gentamicin can also cause renal wasting of these electrolytes. Loop and thiazide-type diuretics may additionally contribute to volume depletion and ototoxicity risk, increasing aminoglycoside toxicity.
What this interaction means in plain words
Chlorthalidone and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive renal electrolyte wasting plus diuretic-induced volume depletion that can reduce aminoglycoside clearance.
What to do
Monitor potassium, magnesium and renal function, and replace deficits promptly. Maintain hydration and monitor gentamicin levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Gentamicin?
MediHelp rates the interaction as moderate. Chlorthalidone and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone causes potassium and magnesium loss, and gentamicin can also cause renal wasting of these electrolytes. Loop and thiazide-type diuretics may additionally contribute to volume depletion and ototoxicity risk, increasing aminoglycoside toxicity.
How serious is the interaction between Chlorthalidone and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, magnesium and renal function, and replace deficits promptly. Maintain hydration and monitor gentamicin levels.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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