Drug interactions
Chlorthalidone + Hydrochlorothiazide-lisinopril
Severity: Moderate
Chlorthalidone and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone duplicates the thiazide-type diuretic already in the combination, increasing the risk of hypokalemia, hyponatremia, hypotension and renal impairment. Lisinopril only partly offsets potassium loss.
What this interaction means in plain words
Chlorthalidone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Therapeutic duplication with additive inhibition of the sodium-chloride cotransporter.
What to do
Avoid using two thiazide-type diuretics together and keep only one. If continued, monitor electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Chlorthalidone and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone duplicates the thiazide-type diuretic already in the combination, increasing the risk of hypokalemia, hyponatremia, hypotension and renal impairment. Lisinopril only partly offsets potassium loss.
How serious is the interaction between Chlorthalidone and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together and keep only one. If continued, monitor electrolytes and renal function.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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