Drug interactions
Chlorthalidone + Indacaterol-glycopyrronium
Severity: Moderate
Chlorthalidone and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics such as chlorthalidone cause potassium loss, and beta-2 agonists can lower potassium further. Resulting hypokalemia may increase the risk of arrhythmias.
What this interaction means in plain words
Chlorthalidone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium wasting and beta-2-mediated cellular potassium uptake.
What to do
Monitor serum potassium periodically and replace it when low. Consider a potassium-sparing agent if hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Chlorthalidone and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics such as chlorthalidone cause potassium loss, and beta-2 agonists can lower potassium further. Resulting hypokalemia may increase the risk of arrhythmias.
How serious is the interaction between Chlorthalidone and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace it when low. Consider a potassium-sparing agent if hypokalemia persists.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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