Drug interactions
Chlorthalidone + Lornoxicam
Severity: Moderate
Chlorthalidone and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can blunt the antihypertensive and diuretic effect of chlorthalidone. Together they also increase the risk of acute kidney injury, especially in volume-depleted or elderly patients. Potassium effects are variable and secondary.
What this interaction means in plain words
Chlorthalidone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal perfusion, opposing diuretic action.
What to do
Use the lowest effective NSAID dose for the shortest time and monitor blood pressure, renal function and potassium. Maintain hydration and consider a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Lornoxicam
Frequently asked questions
Can I take Chlorthalidone with Lornoxicam?
MediHelp rates the interaction as moderate. Chlorthalidone and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can blunt the antihypertensive and diuretic effect of chlorthalidone. Together they also increase the risk of acute kidney injury, especially in volume-depleted or elderly patients. Potassium effects are variable and secondary.
How serious is the interaction between Chlorthalidone and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time and monitor blood pressure, renal function and potassium. Maintain hydration and consider a non-NSAID analgesic.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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