Drug interactions
Chlorthalidone + Saxagliptin
Severity: Moderate
Chlorthalidone and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise blood glucose and so reduce the effect of saxagliptin. The impact is usually modest.
What this interaction means in plain words
Chlorthalidone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity oppose the hypoglycemic effect.
What to do
Monitor blood glucose and HbA1c after starting or changing chlorthalidone and adjust therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Chlorthalidone with Saxagliptin?
MediHelp rates the interaction as moderate. Chlorthalidone and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone can raise blood glucose and so reduce the effect of saxagliptin. The impact is usually modest.
How serious is the interaction between Chlorthalidone and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing chlorthalidone and adjust therapy if needed.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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