Drug interactions
Chlorzoxazone + Doxepin
Severity: Moderate
Chlorzoxazone and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong antihistaminic effects, and chlorzoxazone also causes drowsiness. The combination can cause excessive sedation and impaired coordination.
What this interaction means in plain words
Chlorzoxazone and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression from H1 antagonism by doxepin and the central muscle relaxant effect of chlorzoxazone.
What to do
Monitor for oversedation and falls, particularly in older adults. Consider a lower chlorzoxazone dose or timing doses to limit daytime impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Doxepin?
MediHelp rates the interaction as moderate. Chlorzoxazone and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong antihistaminic effects, and chlorzoxazone also causes drowsiness. The combination can cause excessive sedation and impaired coordination.
How serious is the interaction between Chlorzoxazone and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, particularly in older adults. Consider a lower chlorzoxazone dose or timing doses to limit daytime impairment.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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