Drug interactions
Chlorzoxazone + Lemborexant
Severity: Moderate
Chlorzoxazone and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are CNS depressants, so together they can increase somnolence and next-day impairment. Chlorzoxazone is also reported to be a weak CYP3A4 inhibitor, which could raise lemborexant exposure.
What this interaction means in plain words
Chlorzoxazone and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible weak CYP3A4 inhibition reducing lemborexant clearance.
What to do
Use the lowest effective lemborexant dose and monitor for daytime sedation. Counsel the patient about driving and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorzoxazone and Lemborexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorzoxazone
Other interactions of Lemborexant
Frequently asked questions
Can I take Chlorzoxazone with Lemborexant?
MediHelp rates the interaction as moderate. Chlorzoxazone and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are CNS depressants, so together they can increase somnolence and next-day impairment. Chlorzoxazone is also reported to be a weak CYP3A4 inhibitor, which could raise lemborexant exposure.
How serious is the interaction between Chlorzoxazone and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and monitor for daytime sedation. Counsel the patient about driving and falls.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
