Drug interactions
Chlorzoxazone + Levetiracetam
Severity: Moderate
Chlorzoxazone and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, so taking them together may produce greater sedation and impaired psychomotor performance than either drug alone. This can affect driving and increase the risk of falls.
What this interaction means in plain words
Chlorzoxazone and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excessive sedation, especially when starting or increasing doses, and advise patients to avoid driving until the response is known. Reduce the dose of one agent if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Levetiracetam
Frequently asked questions
Can I take Chlorzoxazone with Levetiracetam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, so taking them together may produce greater sedation and impaired psychomotor performance than either drug alone. This can affect driving and increase the risk of falls.
How serious is the interaction between Chlorzoxazone and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, especially when starting or increasing doses, and advise patients to avoid driving until the response is known. Reduce the dose of one agent if sedation becomes problematic.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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