Drug interactions
Chlorzoxazone + Maprotiline
Severity: Moderate
Chlorzoxazone and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant, and with chlorzoxazone it can produce additive drowsiness and psychomotor impairment. Hypotension and dizziness may also be more noticeable.
What this interaction means in plain words
Chlorzoxazone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression, with maprotiline adding antihistaminic and anti-adrenergic effects.
What to do
Monitor for oversedation and orthostatic hypotension, and advise caution with driving. Adjust the dose of one agent if sedation interferes with function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Maprotiline?
MediHelp rates the interaction as moderate. Chlorzoxazone and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant, and with chlorzoxazone it can produce additive drowsiness and psychomotor impairment. Hypotension and dizziness may also be more noticeable.
How serious is the interaction between Chlorzoxazone and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic hypotension, and advise caution with driving. Adjust the dose of one agent if sedation interferes with function.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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