Drug interactions
Chlorzoxazone + Metaxalone
Severity: Moderate
Chlorzoxazone and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are centrally acting skeletal muscle relaxants that cause drowsiness. Using them together offers no clear therapeutic advantage and increases sedation and dizziness.
What this interaction means in plain words
Chlorzoxazone and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from two muscle relaxants.
What to do
Avoid combining two muscle relaxants where possible and use a single agent. If both are used, monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Metaxalone?
MediHelp rates the interaction as moderate. Chlorzoxazone and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are centrally acting skeletal muscle relaxants that cause drowsiness. Using them together offers no clear therapeutic advantage and increases sedation and dizziness.
How serious is the interaction between Chlorzoxazone and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two muscle relaxants where possible and use a single agent. If both are used, monitor for oversedation.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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