Drug interactions
Chlorzoxazone + Methocarbamol
Severity: Moderate
Chlorzoxazone and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are centrally acting skeletal muscle relaxants that cause drowsiness and dizziness. Taken together they can produce excessive sedation and impair psychomotor performance, and there is little reason to combine two agents of the same class.
What this interaction means in plain words
Chlorzoxazone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from two centrally acting muscle relaxants.
What to do
Avoid therapeutic duplication and use a single muscle relaxant where possible. If both are given, monitor for oversedation and advise against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Methocarbamol?
MediHelp rates the interaction as moderate. Chlorzoxazone and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are centrally acting skeletal muscle relaxants that cause drowsiness and dizziness. Taken together they can produce excessive sedation and impair psychomotor performance, and there is little reason to combine two agents of the same class.
How serious is the interaction between Chlorzoxazone and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication and use a single muscle relaxant where possible. If both are given, monitor for oversedation and advise against driving or operating machinery.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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