Drug interactions
Chlorzoxazone + Nalbuphine
Severity: Moderate
Chlorzoxazone and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness and dizziness. Together with nalbuphine, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Chlorzoxazone and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression; chlorzoxazone's central effects combine with opioid receptor activity.
What to do
Use the lowest effective doses and monitor for excessive sedation. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Nalbuphine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness and dizziness. Together with nalbuphine, sedation and psychomotor impairment may be increased.
How serious is the interaction between Chlorzoxazone and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation. Advise against driving until the response is known.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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