Drug interactions
Chlorzoxazone + Orphenadrin
Severity: Moderate
Chlorzoxazone and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are centrally acting muscle relaxants that cause drowsiness and dizziness. Taken together they may cause greater sedation and impair coordination and alertness.
What this interaction means in plain words
Chlorzoxazone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Avoid combining two muscle relaxants where possible. If used together, give the lowest doses and counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Orphenadrin?
MediHelp rates the interaction as moderate. Chlorzoxazone and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are centrally acting muscle relaxants that cause drowsiness and dizziness. Taken together they may cause greater sedation and impair coordination and alertness.
How serious is the interaction between Chlorzoxazone and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two muscle relaxants where possible. If used together, give the lowest doses and counsel on driving and fall risk.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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