Drug interactions
Chlorzoxazone + Oxymorphone
Severity: Moderate
Chlorzoxazone and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause drowsiness, dizziness and impaired coordination. Respiratory depression is possible, particularly at higher doses.
What this interaction means in plain words
Chlorzoxazone and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and the centrally acting muscle relaxant effect of chlorzoxazone.
What to do
Use the lowest effective doses and monitor sedation and respiratory status. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Oxymorphone?
MediHelp rates the interaction as moderate. Chlorzoxazone and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause drowsiness, dizziness and impaired coordination. Respiratory depression is possible, particularly at higher doses.
How serious is the interaction between Chlorzoxazone and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status. Advise patients to avoid driving and alcohol.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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