Drug interactions
Chlorzoxazone + Quetiapine
Severity: Moderate
Chlorzoxazone and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is strongly sedating, and with chlorzoxazone may cause additive drowsiness, dizziness and orthostatic hypotension. Falls and impaired alertness are the main concerns.
What this interaction means in plain words
Chlorzoxazone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with quetiapine histaminic and alpha-1 blockade.
What to do
Monitor for sedation and orthostatic hypotension, especially in older patients. Counsel on driving and consider dose reduction if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Chlorzoxazone with Quetiapine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is strongly sedating, and with chlorzoxazone may cause additive drowsiness, dizziness and orthostatic hypotension. Falls and impaired alertness are the main concerns.
How serious is the interaction between Chlorzoxazone and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, especially in older patients. Counsel on driving and consider dose reduction if symptomatic.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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