Drug interactions
Chlorzoxazone + Thioridazine
Severity: Moderate
Chlorzoxazone and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is sedating and can cause orthostatic hypotension, so combined use with chlorzoxazone may increase drowsiness and falls. The main hazard of thioridazine, QT prolongation, is not clearly affected by chlorzoxazone.
What this interaction means in plain words
Chlorzoxazone and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and orthostatic hypotension, and counsel on driving. Maintain routine ECG and electrolyte monitoring for thioridazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Thioridazine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thioridazine is sedating and can cause orthostatic hypotension, so combined use with chlorzoxazone may increase drowsiness and falls. The main hazard of thioridazine, QT prolongation, is not clearly affected by chlorzoxazone.
How serious is the interaction between Chlorzoxazone and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, and counsel on driving. Maintain routine ECG and electrolyte monitoring for thioridazine.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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