Drug interactions
Chlorzoxazone + Ziprasidone
Severity: Moderate
Chlorzoxazone and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combining chlorzoxazone with ziprasidone can produce additive drowsiness, dizziness and slowed reactions. Elderly or frail patients are at greater risk of falls.
What this interaction means in plain words
Chlorzoxazone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excess sedation and orthostatic symptoms, especially after dose changes. Advise patients against driving until the effect of the combination is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Ziprasidone?
MediHelp rates the interaction as moderate. Chlorzoxazone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combining chlorzoxazone with ziprasidone can produce additive drowsiness, dizziness and slowed reactions. Elderly or frail patients are at greater risk of falls.
How serious is the interaction between Chlorzoxazone and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and orthostatic symptoms, especially after dose changes. Advise patients against driving until the effect of the combination is known.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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