Drug interactions
Cholera vaccine + Hydroxychloroquine
Severity: Moderate
Cholera vaccine and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine-type antimalarials have been shown to reduce the antibody response to oral cholera vaccine. Hydroxychloroquine may do the same, though the data are limited. Protection against cholera could be lower in treated patients.
What this interaction means in plain words
Cholera vaccine and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Hydroxychloroquine may impair immune response or vaccine strain replication; the exact mechanism is not firmly established.
What to do
Give the oral cholera vaccine at least 10 days before starting hydroxychloroquine where feasible, and reinforce hygiene precautions in travelers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Cholera vaccine and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine-type antimalarials have been shown to reduce the antibody response to oral cholera vaccine. Hydroxychloroquine may do the same, though the data are limited. Protection against cholera could be lower in treated patients.
How serious is the interaction between Cholera vaccine and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the oral cholera vaccine at least 10 days before starting hydroxychloroquine where feasible, and reinforce hygiene precautions in travelers.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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