Drug interactions
Cholera vaccine + Penicillin g procaine-penicillin g
Severity: Moderate
Cholera vaccine and Penicillin g procaine-penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live attenuated cholera vaccine contains a living bacterial strain that can be killed by antibiotics. Recent antibiotic exposure may therefore reduce vaccine take and the protective immune response.
What this interaction means in plain words
Cholera vaccine and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain prevents adequate colonisation and immunogenicity.
What to do
Do not give the vaccine to patients who have received systemic antibiotics within the previous 14 days. Defer vaccination until the antibiotic course is complete and the interval has passed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g procaine-penicillin g
- Amifampridine + Penicillin g procaine-penicillin g Moderate
- Baricitinib + Penicillin g procaine-penicillin g Moderate
- Microbiota + Penicillin g procaine-penicillin g Moderate
- Omadacycline + Penicillin g procaine-penicillin g Moderate
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Penicillin g procaine-penicillin g + Vadadustat Moderate
Frequently asked questions
Can I take Cholera vaccine with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Cholera vaccine and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live attenuated cholera vaccine contains a living bacterial strain that can be killed by antibiotics. Recent antibiotic exposure may therefore reduce vaccine take and the protective immune response.
How serious is the interaction between Cholera vaccine and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have received systemic antibiotics within the previous 14 days. Defer vaccination until the antibiotic course is complete and the interval has passed.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Baricitinib, Microbiota. The full list is on the Penicillin g procaine-penicillin g page.
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