Drug interactions
Omadacycline + Penicillin g procaine-penicillin g
Severity: Moderate
Omadacycline and Penicillin g procaine-penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines may blunt the bactericidal activity of beta-lactams, which depend on bacterial growth. Clinical evidence is limited, but reduced penicillin effect is theoretically possible in serious infections.
What this interaction means in plain words
Omadacycline and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omadacycline belongs to Anti Bacterial; Penicillin g procaine-penicillin g belongs to Anti Bacterial.
Why it happens
Protein synthesis inhibition slows bacterial growth, reducing the cell-wall-dependent killing of penicillins.
What to do
Avoid the combination in severe infections such as meningitis or endocarditis where bactericidal action is required. Otherwise monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g procaine-penicillin g
- Amifampridine + Penicillin g procaine-penicillin g Moderate
- Baricitinib + Penicillin g procaine-penicillin g Moderate
- Cholera vaccine + Penicillin g procaine-penicillin g Moderate
- Microbiota + Penicillin g procaine-penicillin g Moderate
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Penicillin g procaine-penicillin g + Vadadustat Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Omadacycline with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Omadacycline and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the bactericidal activity of beta-lactams, which depend on bacterial growth. Clinical evidence is limited, but reduced penicillin effect is theoretically possible in serious infections.
How serious is the interaction between Omadacycline and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in severe infections such as meningitis or endocarditis where bactericidal action is required. Otherwise monitor clinical response.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Baricitinib, Cholera vaccine. The full list is on the Penicillin g procaine-penicillin g page.
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