Drug interactions
Penicillin g procaine-penicillin g + Vadadustat
Severity: Moderate
Penicillin g procaine-penicillin g and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillin G is eliminated by renal tubular secretion through organic anion transporters, and inhibition of OAT1/OAT3 can raise vadadustat exposure. Higher vadadustat levels may cause an excessive or too rapid hemoglobin rise and more adverse effects. The clinical significance of penicillin G specifically is uncertain.
What this interaction means in plain words
Penicillin g procaine-penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Penicillin g procaine-penicillin g belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Why it happens
Competition for or inhibition of renal OAT1/OAT3 transport may reduce vadadustat clearance and increase exposure.
What to do
Monitor hemoglobin regularly and reduce the vadadustat dose or interrupt it if hemoglobin rises too quickly or excessively. Watch for adverse effects such as thrombotic events and hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g procaine-penicillin g
- Amifampridine + Penicillin g procaine-penicillin g Moderate
- Baricitinib + Penicillin g procaine-penicillin g Moderate
- Cholera vaccine + Penicillin g procaine-penicillin g Moderate
- Microbiota + Penicillin g procaine-penicillin g Moderate
- Omadacycline + Penicillin g procaine-penicillin g Moderate
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Penicillin g procaine-penicillin g with Vadadustat?
MediHelp rates the interaction as moderate. Penicillin g procaine-penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G is eliminated by renal tubular secretion through organic anion transporters, and inhibition of OAT1/OAT3 can raise vadadustat exposure. Higher vadadustat levels may cause an excessive or too rapid hemoglobin rise and more adverse effects. The clinical significance of penicillin G specifically is uncertain.
How serious is the interaction between Penicillin g procaine-penicillin g and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly and reduce the vadadustat dose or interrupt it if hemoglobin rises too quickly or excessively. Watch for adverse effects such as thrombotic events and hypertension.
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Baricitinib, Cholera vaccine. The full list is on the Penicillin g procaine-penicillin g page.
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