Drug interactions
Microbiota + Penicillin g procaine-penicillin g
Severity: Moderate
Microbiota and Penicillin g procaine-penicillin g: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores that can be inactivated by antibacterials. Concurrent penicillin may reduce the ability of the spores to colonise the gut, lessening efficacy against recurrent C. difficile infection.
What this interaction means in plain words
Microbiota and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity reduces viability and colonisation of the administered bacterial spores.
What to do
Complete the antibiotic course before giving the microbiota product, leaving the interval stated in labeling (2 to 4 days).
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g procaine-penicillin g
- Amifampridine + Penicillin g procaine-penicillin g Moderate
- Baricitinib + Penicillin g procaine-penicillin g Moderate
- Cholera vaccine + Penicillin g procaine-penicillin g Moderate
- Omadacycline + Penicillin g procaine-penicillin g Moderate
- Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Penicillin g procaine-penicillin g + Vadadustat Moderate
Frequently asked questions
Can I take Microbiota with Penicillin g procaine-penicillin g?
MediHelp rates the interaction as moderate. Microbiota and Penicillin g procaine-penicillin g can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota products contain live bacterial spores that can be inactivated by antibacterials. Concurrent penicillin may reduce the ability of the spores to colonise the gut, lessening efficacy against recurrent C. difficile infection.
How serious is the interaction between Microbiota and Penicillin g procaine-penicillin g?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the antibiotic course before giving the microbiota product, leaving the interval stated in labeling (2 to 4 days).
What other medicines interact with Penicillin g procaine-penicillin g?
MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Baricitinib, Cholera vaccine. The full list is on the Penicillin g procaine-penicillin g page.
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