Drug interactions
Cholera vaccine + Ruxolitinib
Severity: Moderate
Cholera vaccine and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib suppresses immune signalling and may blunt the response to the oral cholera vaccine. Protection could be incomplete in treated patients.
What this interaction means in plain words
Cholera vaccine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic immunosuppression by JAK inhibition reduces vaccine-induced immune response.
What to do
Where possible, vaccinate before starting ruxolitinib; otherwise do not assume full protection and reinforce hygiene and water precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Frequently asked questions
Can I take Cholera vaccine with Ruxolitinib?
MediHelp rates the interaction as moderate. Cholera vaccine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ruxolitinib suppresses immune signalling and may blunt the response to the oral cholera vaccine. Protection could be incomplete in treated patients.
How serious is the interaction between Cholera vaccine and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting ruxolitinib; otherwise do not assume full protection and reinforce hygiene and water precautions.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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