Drug interactions
Cholera vaccine + Tigecycline
Severity: Moderate
Cholera vaccine and Tigecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut, and systemic antibiotics with activity against the strain may reduce its effect. Tigecycline is given intravenously, but it has broad activity and may still impair the immune response.
What this interaction means in plain words
Cholera vaccine and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic activity against the live attenuated vaccine strain reduces its replication and immunogenicity.
What to do
Avoid giving the live oral cholera vaccine during antibiotic therapy and delay vaccination for at least 14 days after the antibiotic course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tigecycline
Frequently asked questions
Can I take Cholera vaccine with Tigecycline?
MediHelp rates the interaction as moderate. Cholera vaccine and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut, and systemic antibiotics with activity against the strain may reduce its effect. Tigecycline is given intravenously, but it has broad activity and may still impair the immune response.
How serious is the interaction between Cholera vaccine and Tigecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live oral cholera vaccine during antibiotic therapy and delay vaccination for at least 14 days after the antibiotic course.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Microbiota. The full list is on the Tigecycline page.
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