Drug interactions
Mipomersen + Tigecycline
Severity: Moderate
Mipomersen and Tigecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Using them together may add to liver injury risk and make it harder to attribute enzyme elevations.
What this interaction means in plain words
Mipomersen and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential hepatotoxicity through separate mechanisms.
What to do
Check liver enzymes and bilirubin before and during combined use. Stop or reassess therapy if enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tigecycline
Frequently asked questions
Can I take Mipomersen with Tigecycline?
MediHelp rates the interaction as moderate. Mipomersen and Tigecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Using them together may add to liver injury risk and make it harder to attribute enzyme elevations.
How serious is the interaction between Mipomersen and Tigecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before and during combined use. Stop or reassess therapy if enzymes rise significantly.
What other medicines interact with Tigecycline?
MediHelp also lists interactions of Tigecycline with, for example, Typhoid vaccine live, Bcg vaccine live, Cholera vaccine. The full list is on the Tigecycline page.
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