Drug interactions
Cholera vaccine + Upadacitinib
Severity: Moderate
Cholera vaccine and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Upadacitinib may blunt the immune response to cholera vaccine, leaving the patient less protected. The oral cholera vaccine is live attenuated, so replication in an immunosuppressed host is a theoretical concern.
What this interaction means in plain words
Cholera vaccine and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression reduces vaccine immunogenicity and impairs control of live attenuated organisms.
What to do
Vaccinate at least 2 to 4 weeks before starting upadacitinib when possible. Otherwise confirm the response and consider alternative protective measures for travel.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Upadacitinib Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Upadacitinib?
MediHelp rates the interaction as moderate. Cholera vaccine and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Upadacitinib may blunt the immune response to cholera vaccine, leaving the patient less protected. The oral cholera vaccine is live attenuated, so replication in an immunosuppressed host is a theoretical concern.
How serious is the interaction between Cholera vaccine and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 to 4 weeks before starting upadacitinib when possible. Otherwise confirm the response and consider alternative protective measures for travel.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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