Drug interactions
Cholestyramine + Diclofenac
Severity: Moderate
Cholestyramine and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine can bind oral diclofenac in the gut and reduce its absorption, which may lessen pain relief.
What this interaction means in plain words
Cholestyramine and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
Anion-exchange resin binds diclofenac in the gastrointestinal tract, reducing absorption.
What to do
Give diclofenac at least 1 hour before or 4 to 6 hours after cholestyramine, and monitor analgesic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Diclofenac?
MediHelp rates the interaction as moderate. Cholestyramine and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine can bind oral diclofenac in the gut and reduce its absorption, which may lessen pain relief.
How serious is the interaction between Cholestyramine and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give diclofenac at least 1 hour before or 4 to 6 hours after cholestyramine, and monitor analgesic response.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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