Drug interactions
Cholestyramine + Enalapril-hydrochlorothiazide
Severity: Moderate
Cholestyramine and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces its absorption, weakening the diuretic and antihypertensive effect. Enalapril may also be affected to some degree.
What this interaction means in plain words
Cholestyramine and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Anion-exchange resin binds the drug in the gastrointestinal tract, reducing absorption.
What to do
Give the combination tablet at least 4 hours before cholestyramine, or at least 4 to 6 hours after it as per labeling. Monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cholestyramine and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds hydrochlorothiazide in the gut and markedly reduces its absorption, weakening the diuretic and antihypertensive effect. Enalapril may also be affected to some degree.
How serious is the interaction between Cholestyramine and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the combination tablet at least 4 hours before cholestyramine, or at least 4 to 6 hours after it as per labeling. Monitor blood pressure.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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